Chemical-Induced Phenotypes at CTD Help Inform the Predisease State and Construct Adverse Outcome Pathways

  12/3/2018

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At the journal club held on Dec 3, 2018 (Azar 12, 97), the interesting topic entitled" The help of chemical-induced phenotypes at CTD to inform the predisease state and construct adverse outcome pathways" was discussed. A summary of this journal club meeting is in below:
The Comparative Toxicogenomics Database (CTD; http://ctdbase.org) is a public resource that manually curates the scientific literature to provide content that illuminates the molecular mechanisms by which environmental exposures affect human health. This database describes how chemicals can affect molecular, cellular, and physiological phenotypes. At CTD, phenotypes and diseases are operationally distinguished, wherein a phenotype refers to a nondisease biological event: eg, decreased cell cycle arrest (phenotype) versus liver cancer (disease), increased fat cell proliferation (phenotype) versus morbid obesity (disease), etc. Chemical-phenotype interactions are expressed in a formal structured notation using controlled terms for chemicals, phenotypes, taxon, and anatomical descriptors. Combining this information with CTD’s chemical-disease module allows inferences to be made between phenotypes and diseases, yielding potential insight into the predisease state. Integration of all 4 CTD modules furnishes unique opportunities for toxicologists to generate computationally predictive adverse outcome pathways, linking chemicalgene molecular initiating events with phenotypic key events, adverse diseases, and population-level health outcomes.