TIPS of the Tehran University of Medical Sciences

The Institute of Pharmaceutical Sciences (TIPS) is a new name for Pharmaceutical Sciences Research Center (PSRC) which was officially launched from February 2018. Drug Design and Development Research Center, and Pharmaceutics Quality Assurance Research Center are two joint centers of TIPS. TIPS tries to spread interest in research among students, to recruit and support researchers at all academic levels, to conduct both fundamental and applied ...

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جلسه هم اندیشی با اعضای گروههای تخصصی پژوهشکده

اولین جلسه هم اندیشی با اعضای گروههای تخصصی پژوهشکده 18 دی ماه 1397 تشکیل شد. در این جلسه دکتر خوشایند و دکتر خوبی سرپرستان گروههای تخصصی کمومتریکش و زیست مواد به تشریح فعالیت های خود پرداختند. دکتر عبداللهی رییس پژوهشکده با تشریح آخرین وضعیت پژوهشکده از همه اعضا خواست ضمن افزایش سرعت و دقت انجام امور به ویژه برای افزایش ارتباط با جامعه و رفع مشکلات، از مرحله پژوهش های بنیادی به پژوهش های کاربردی حرکت کنند.
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کارگاه آشنایی با بیوانفورماتیک میکرو آر ان ای و کاربردهای آن در پژوهشکده علوم دارویی تشکیل شد

این کارگاه با هدف آشنایی مقدماتی با زیست‌شناسی میکرو آر ان ای و انواع پایگاه داده‌های آن در تاریخ ۱۹ دی ماه، با تدریس دکتر پریسا صحرانوردفرد و با حضور ۱۵ نفر از اساتید، دانشجویان و همچنین کارشناسان پژوهشکده علوم دارویی برگزار شد. در بخش اول، توضیحاتی در مورد مکانیسم عمل RNA تداخل‌گر، کاربردهای آن و سپس نحوه بیوژنز و عملکرد microRNA به عنوان یکی از عوامل اپی‌ژنتیکی تنظیم بیان ژن داده شد. در ادامه، انواع پایگاه داده‌های microRNA معرفی شده و کاربرد هر کدام به صورت عملی توضیح داده شد. در بخش پایانی کارگاه، هر کدام از شرکت‌کنندگان با توجه به زمینه کاری خود، با استفاده از پایگاه داده GEO داده‌های یکی از مطالعات موجود را آنالیز کرده و با نحوه استفاده از داده‌های high throughput آشنا شدند و داده‌های بدست آمده را توسط پایگاه‌های Enrichment مورد بررسی دقیق‌تر قرار دادند.
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A lecture on "possible ways to avoid plagiarism" in TIPS

A lecture on “possible ways to avoid plagiarism” was held by Prof. Mohammad Abdollahi on January 14, 2019 at the school of pharmacy, TUMS. A brief report of can be found in below. Plagiarism as one of the important threats to the integrity of published articles is considered and as a result, journals are very alert to the possible plagiarism in the manuscripts they receive. Plagiarism detection software such as iThenticate could be used in reducing the possibility of duplicate publication enhancing the quality of the papers. Further, most of the editors do not accept direct copying and pasting of the content, in which the text must be reworded and accompanied by appropriate citations. However, some editors may be more tolerant of some similarity in the Materials and Methods section of an academic paper, because this section usually contains technical terms and a typical style of writing that cannot be revised drastically. Many journal editors seem to understand the limitations of a plagiarism detection tool and use it with discretion, in consultation with the authors or peer reviewers.

Journal Clubs

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    Journey to the Center of the Fetal Brain: Environmental Exposures and Autophagy

    At the TIPS journal club meeting held on December 24, 2018, the topic of “Journey to the Center of the Fetal Brain: Environmental Exposures and Autophagys” was presented by Dr. Kayvan Mirnia, the TIPS invited speaker. Dr. Mirnia is an Assistant professor of Neonatology in children's hospital centre, Tehran University of Medical Sciences. In this presentation environmental effects on fetal brain development were discussed. Later on, mechanisms regarding environmental effects on cellular autophagy and its translation in clinic especially in case of IUGR hypotonia asphyxia spasticity were discussed. It is known that the cause of asphyxia spasticity might be due to the genetic background or some other metabolic disease. Considering other factors and biomarker like autophagosomal marker, chain (LC3) may give us a deeper insight regarding this disorder.

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    Wnt signaling pathway

    At the TIPS journal club meeting held on December 31, 2018, the topic of “Wnt signaling pathways” was presented by Madiha Khalid. A summary of this presentation is in below. Wnt signaling pathways characterized into canonical (β-catenin dependent) and noncanonical (β-catenin independent). Canonical Wnt signaling or Wnt/β-catenin signaling regulates cell fate determination during development. An absence of Wnt protein extracellularly results into activation of β-catenin destruction complex which consists of two scaffold proteins i.e. Axin and APC and two kinases enzymes i.e. CK1 and GSK3 responsible for β-catenin phosphorylation at its amino terminus. Phosphorylated β-catenin recognized by F-box protein β-TrCP which along SCF ubiquitin ligase ubiquitinates β-catenin leading to its proteolysis by the proteasome. This results into the low β-catenin level and preventing its translocation to the nucleus thereby repressing Wnt target genes by the DNA-bound TCF/LEF. In the presence of Wnt protein extracellularly, it forms a Wnt-Fz-LRP6/5 complex upon binding to Fz receptor and its co-receptors LRP6/5. Wnt-Fz-LRP6/5 complex recruit cytosolic protein Dv1 engaging Axin along kinases enzymes CK1 and GSK3 which in turn phosphorylate cytosolic tail of LRP6/5. The phosphorylation of cytosolic tail act as positive feedback causing sequestration of β-catenin destruction complex consequently stabilizing and accumulating cytoplasmic β-catenin to enter into the nucleus to form complexes with TCF/LEF and finally activating Wnt target gene expression.

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    Releasing genetically modified organism(GMO) will any harm outweigh any advantage?

    At the TIPS journal club meeting held on January 7, 2019, the topic of “Releasing genetically modified organism(GMO) will any harm outweigh any advantage” was presented by M. R. Hooshangi. A summary of this presentation is in below. Genetic modification is a special set of gene technology that alters the genetic machinery of such living organisms as animals, plants or microorganisms. Combining genes from different organisms is known as recombinant DNA technology and the resulting organism is said to be ‘ Genetically modified (GM) ’ , ‘ Genetically engineered ’ or ‘ Transgenic ’ . The principal transgenic crops grown commercially in field are herbicide and insecticide resistant soybeans, corn, cotton and canola. Other crops grown commercially and/or field-tested are sweet potato resistant to a virus that could destroy most of the African harvest, rice with increased iron and vitamins that may alleviate chronic malnutrition in Asian countries and a variety of plants that are able to survive weather extremes. There are bananas that produce human vaccines against infectious diseases such as hepatitis B, fish that mature more quickly, fruit and nut trees that yield years earlier and plants that produce new plastics with unique properties. Technologies for genetically modifying foods offer dramatic promise for meeting some areas of greatest challenge for the 21st century.

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    Effects of needle size on inflammation during cecal legation and puncture

    At TIPS journal club meeting held on January 14, 2019, the topic of “Effects of needle size on inflammation during cecal legation and puncture” was presented by T. Didari. A summary of this presentation is in below. Sepsis as a result of host and pathogens interaction causes the organ damage and plays a critical role for wide range of intensive care unit (ICU) and emergency department (ED) patients. This study is designed to evaluate the outcome of the CLP procedure in murine models using two routine needle sizes, 18 and 21. To this end, rats were randomly assigned into CLP procedure with gauge 18, 21, and the sham. Oxidative stress markers, blood markers, apoptosis indicators, and gene expression of autophagy and cellular hypoxia were measured in all animals. Besides, histopathological assessments were carried out and the levels of inflammatory cytokines such as (TNF-α) and (HMGB1) were measured in both cardiac and pulmonary tissues 24 hours after the procedure. The results indicated that although all measured factors increased in both 18 and 21 gauge groups in comparison with the shams, inflammatory markers, blood markers, blood and tissue lactate levels, pro-inflammatory cytokines, 3 and 9 caspases, gene expression of cellular homeostasis and autophagy in tissue samples were most prominently increased in the gauge 18 group in comparison with the gauge 21 ones 24 hours following the procedure. Our findings indicate that in murine models of sepsis induced by CLP procedure, gauge size can be influential in the outcomes. More specifically, using gage 18 needles leads to superior results in comparison with gage 21ones.