Secondary Fungal infections in patients on Broad spectrum antibiotics in ICU setup



At the TIPS journal club meeting held on November 26, 2018 (Azar 5, 97) a topic on the topic ‘’Secondary Fungal Infections in Patients on Broad Spectrum Antibiotics in ICU Setup’’ was discussed by Fazli Azim. At the beginning of his presentation he explained the human body, which contains about Trillions of cells, routinely harbors about one 100 Trillions bacteria in which bacterial population constitutes the normal microbial flora. The normal flora influences the anatomy, physiology, susceptibility to pathogens, and morbidity of the host in critically ill patient’s normal bacterial flora damages due to weakening of immune system and the opportunistic fungi that are a part of our normal flora becomes invasive and caused secondary fungal infections. Later on he determined that the Infections have almost become an inseparable part of the ICU throughout the globe in spite of numerous advancements in diagnostic and therapeutic interventions. Of the various infections prevalent in an intensive care unit, invasive fungal infection has always been considered to occur infrequently, with the surge in broad-spectrum antibiotic usage. Endogenous (Opportunistic) Candida, Cryptococcus, Aspergillus etc causes infections. Candidiasis is the leading cause of fungal infections in the ICU (Intensive Care Unit), ranging from 1 to 10/1000 ICU admissions and is an important cause of morbidity and mortality in ICU patients. At the end he concluded that risk factors include i-e prolong stay in ICU with antibiotics usage, mechanical ventilation, O2 therapy, organ transplantation etc. Early diagnosis and best possible interventions can reduce the mortality rate and also reduction in morbidity and improves patient quality of life.