TIPS of the Tehran University of Medical Sciences

The Institute of Pharmaceutical Sciences (TIPS) is a new name for Pharmaceutical Sciences Research Center (PSRC) which was officially launched from February 2018. Drug Design and Development Research Center, and Pharmaceutics Quality Assurance Research Center are two joint centers of TIPS. TIPS tries to spread interest in research among students, to recruit and support researchers at all academic levels, to conduct both fundamental and applied ...

Read more »

Latest News   Archive

...

Ethics Workshop in TIPS

برگزاری کارگاه "ملاحظات اخلاقی در پژوهش های علوم دارویی" در پژوهشکده علوم دارویی
...

Scientific Council Meeting- October 2018

TIPS scientific groups meeting was held on 14 October 2018 and usual issues of TIPS were disscussed.
...

نشست صمیمی دکتر نمازی با رییس و اعضای پژوهشکده علوم دارویی

دکتر نمازی مدیر توسعه سازمان و سرمایه انسانی دانشگاه در نشستی صمیمانه با رییس و اعضای پژوهشکده علوم دارویی شرکت کرد. در این جلسه که در تاریخ 28 آبان 1397 تشکیل شد هر کدام از اعضا با معرفی خود به بیان مشکلات حوزه فعالیتیشان پرداخته و دکتر نمازی به تمام سوالات آنها پاسخ داد.
...

عملکرد پژوهشکده علوم دارویی در هیات رییسه دانشگاه بررسی شد

در نشست هیات رییسه دانشگاه، پژوهشکده علوم دارویی به عنوان نخستین مرکز، گزارش عملکرد خود را ارایه کرد و برنامه رتبه‌بندی معاونت بین‌الملل بررسی شد.

Journal Clubs

  • ...

    Destructive effect of non-enzymatic glycation on catalase and remediation via curcumin

    In the journal club meeting held on October 22, 2018, Dr. Faezeh Mofidi presented her topic. Non-enzymatic glycation of proteins is a post-translational modification produced by a covalent binding between one molecule of glucose and free Ɛ- amino group of amino acid specially lysine residue. The effect of pathological conditions, derived from hyperglycemia on catalase as an important antioxidant enzyme was considered by measuring enzyme activity, amount of reactive oxygen species (ROS) production, and changes in catalase conformational properties. It is observed that in the presence of glucose, the catalase activity gradually decreased with an increase in the ROS generation. Changes in the structure of the enzyme were also considered as another result of glycation. However, inhibitory effect of curcumin on structural changes and activity decrease of catalase were also investigated using experimental and computational methods. It was showed that interaction of catalase with curcumin resulted in changes in accessible surface area (ASA) and pKa as two effective parameters of glycation.

  • ...

    Applications of Flowcytometry in Research

    At the journal club meeting held on October 29, 2018, basic principle of flow cytometry and its application in medical researches was discussed. Flow cytometry as an instrument capable of simultaneous measuring characteristics of cells such as size and granularity was introduced. Additionally, the basic understanding of flow cytometry technology essential for all users in combination with the methods used to analyse and interpret the data were discussed. Moreover, the potential of Fluorescence-Activated Cell Sorter (FACS) method in comparison with flow cytometry for toxicology applications was introduced.

  • ...

    Identification of Nontoxic Substructures: A New Strategy to Avoid Potential Toxicity Risk

    At the journal club meeting held on November 5, 2018, computer based toxicity topic was discussed. In this presentation a new strategy to avoid potential toxicity risk based on the assumption that some substructures may affect the impact of certain SAs and thus “neutralize” the toxicity of compounds was introduced. In order to identify compounds with potential toxicity problems, particular attention is paid to structural alerts, which are high chemical reactivity molecular fragments. The concept has been introduced in order to reduce the likelihood that future candidate substances as pharmaceuticals will have undesirable toxic effects. A significant proportion of drugs characterized by residual toxicity contain substructural alerts. However, there are still some marketed drugs containing substructural alert, which indicates that substructural alert should be analyzed carefully to avoid their excessive uses.

  • ...

    Applications of preclinical imaging for cell therapy

    At the journal club meeting held on November 12, 2018, the topic of “Applications of preclinical imaging for cell therapy” was discussed by Dr. Ehsan Sharif. In this presentation Dr. Sharif introduced Regulatory T cells (Tregs) as the key in controlling autoimmune diseases and limiting immune responses to foreign antigens. Tregs are being studied for adoptive transfer immunotherapy for various diseases such preventing transplant rejection. Then, he comes up with questions such as where therapeutic Tregs go and how long they stay viable in patients remains unsolved and trying to answer these questions in a pre-clinical set up with the help of nuclear medicine imaging technology. Imaging of the human sodium/iodide symporter (NIS) via Single Photon Emission Computed Tomography (SPECT) has been used to image various cell types in vivo. SPECT/CT imaging can be used to visualise the migratory pattern of Tregs in vivo. Murine Tregs were transduced with a construct encoding for NIS. NIS expressing Tregs were specifically radiolabelled in vitro with Technetium-99m pertechnetate (99mTcO4-) and exposure of these cells to radioactivity did not affect cell viability, phenotype or function. It is demonstrated that this method of imaging can be utilised to image migration of Tregs with direct and indirect allo-specificity in a skin transplant model. Interestingly, Tregs that prolonged the transplant survival demonstrated a different pattern of migration compared to Tregs that were unable to prolong the transplant survival.