TIPS of the Tehran University of Medical Sciences

The Institute of Pharmaceutical Sciences (TIPS) is a new name for Pharmaceutical Sciences Research Center (PSRC) which was officially launched from February 2018. Drug Design and Development Research Center, and Pharmaceutics Quality Assurance Research Center are two joint centers of TIPS. TIPS tries to spread interest in research among students, to recruit and support researchers at all academic levels, to conduct both fundamental and applied ...

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بازدید نماینده و عضو کمیسیون صنایع و معادن مجلس از پژوهشکده علوم دارویی

مهندس منصوری نماینده شهرستان ساوه و عضو کمیسیون صنایع و معادن مجلس در راستای ارتباط دانشگاه با صنعت و جامعه از پژوهشکده علوم دارویی بازدید به عمل آورد.
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Defence meeting of Mehdi Mogharrabi, PhD student of TIPS

On 16 February 2019, Mehdi Mogharrabi, TIPS's PhD student of Pharmaceutical Sciences did his thesis final defense during a meeting in front of the internal and external referees.
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برگزاری آخرین جلسات شورای محیطی ارتباط با صنعت، شورای علمی، و کمیته اخلاق سازمانی سال 97 در پژوهشکده علوم دارویی

پژوهشکده علوم دارویی میزبان برگزاری جلسات شورای محیطی ارتباط با صنعت، شورای علمی، و کمیته اخلاق سازمانی در تاریخ 5 اسفند 97 بود.
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دانشجوی بین الملل پژوهشکده علوم دارویی برگزیده پنجمین جشنواره دانشجویی ابن سینا

فضل الله خان دانشجوی دکترای تخصصی پژوهشکده علوم دارویی به عنوان برگزیده بخش دانشجویی جامع بین الملل در پنجمین جشنواره دانشجویی ابن سینا در سال 97 معرفی شد.

Journal Clubs

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    Modeling Large Molecules Using the ONIOM Method Implemented in Gaussian Program

    At TIPS journal club meeting held on February 18, 2019, the topic of “Modeling Large Molecules Using the ONIOM Method Implemented in Gaussian Program” was presented by Dr. Jalalimanesh. A brief summary of this presentation is in below. The ONIOM (our own n-layered integrated molecular orbital and molecular mechanics) is a computational approach developed by Morokuma and co-workers. ONIOM is a hybrid or multiscale method that attempts to combine the accuracy of quantum mechanics with the speed of molecular mechanics. In an ONIOM method, a large molecule is divided into multiple fragments. Different theoretical methods, ranging from very expensive and accurate methods to less expensive and accurate methods, are then applied to the different fragments to produce reliable geometry and energy at reduced computational time. In the last two decades, ONIOM has been widely and successfully applied to study the structure and structure-related properties of biological systems (such as proteins and DNA/RNA). This method can serve as a powerful tool to model reaction mechanisms of pharmaceutically relevant targets, and for studying binding phenomena found within pharmaceutical drug discovery programs.

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    Polymer brush coating decorated with antibiotics for prevention of catheter associated-infections

    At TIPS journal club meeting held on February 25, 2019, the topic of “Polymer brush coating decorated with antibiotics for prevention of catheter associated-infections” was presented by M. Hassani. A brief summary of this presentation is in below. One of the main causes of Biomedical implant failure is implant-related infection in which the number of patients requiring biomaterials implant surgery is steadily increasing. Treatment of this kind of infected implants includes antibiotic therapy, while the implant removal will be a final decision. In this regards, several strategies have been followed in order to develop anti-adhesive and bactericidal coatings, such as polymer brush coatings, antimicrobial nanostructures and antimicrobial peptides to prevent bacterial adhesion and subsequent infection. The brush coating forms a highly hydrated layer of chains that is compressed upon bacterial approach, leading to a repulsive osmotic force and to a reduced mobility of the polymer chains. This creates a steric barrier which discourages close contact and suppresses bacterial adhesion. In this research, the fate of bacteria that adhere on a polymer brush-coating and determining whether they are able to grow into a biofilm and if so what the effect of brush coatings on viability and adhesion strength of the biofilm will be evaluated.

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    Startup companies: from formation to success

    At TIPS journal club meeting held on March 11, 2019, TIPS invited guest gave a presentation about “Startup companies: from formation to success”. At this session of the TIPS journal club meeting Dr. R. Fazel, director of Livogen Pharmed company gave a lecture about building a startup. He presented his company as a successful knowledgebase startup specialized in the field of Biotechnology. He explained that the company is committed to delivering high quality services and offering a wide range of off-the-shell and customized assays for biopharmaceutical-producing cell line characterization and protein characterization, as well as genetic stability and safety assessments of cell banks to biopharmaceutical and biotechnology industries, and research institutes. Then, he explained about important steps can be taken to achieved a successful startup.

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    How to look at your manuscripts through the eyes of a reviewer?

    At TIPS journal club meeting held on March 04, 2019, the topic of “How to look at your manuscripts through the eyes of a reviewer?” was presented by Dr. M. Daghighi. A brief summary of this presentation is in below. Reviewers see whether the paper is within the scope of the journal, whether the science is good, and whether the paper meets the conceptual novelty standards of the journal. At a manuscript text level, one of the reviewer's priorities is to check the article's internal consistency. By that, it means that do the method and results match? Do the results and conclusion match? A common weakness is that the different sections appear to have been written independently of each other. If the paper is cohesive it is elevated to a whole new level. Other items are that they concentrate on the writing and presentation. The science might be great, but heavy composition and messy structure might bog down the main message. The reviewers may suggest to the authors how to make the story more cohesive and tightly reasoned.