TIPS of the Tehran University of Medical Sciences

The Institute of Pharmaceutical Sciences (TIPS) is a new name for Pharmaceutical Sciences Research Center (PSRC) which was officially launched from February 2018. Drug Design and Development Research Center, and Pharmaceutics Quality Assurance Research Center are two joint centers of TIPS. TIPS tries to spread interest in research among students, to recruit and support researchers at all academic levels, to conduct both fundamental and applied ...

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Latest News   Archive

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Students of TIPS in the list of dominants of 7th Integrated Graduate Students

At the graduation ceremony of the university graduates which was held in the Grand Hall of the Country on Friday, July 22, 1397, Ms. Mona Nawaii and Fatima Esmael, Ph.D. students at the Pharmaceutical Research Institute, were honored as the best trainees.
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The third meeting of Industry Relations Committee

The third meeting of Industry Relations Committee held in the Institute of Pharmaceutical Sciences on 15th July 2017.
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The 8th PhD student admission interview in TIPS

The 8th PhD student admission interview was held on 15 July 2017 in the Institute of Pharmaceutical Sciences and a new student were accepted.
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Resource Finder in now Updated

Access to more than 50 clinical reference books in the 2019 edition is available through "Resource finder".

Journal Clubs

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    Application of nanostructures for preconcentration and determination of biological compounds and elimination of pollutants and drug delivery

    The topic of discussion on 11th June, 2018 at Journal Club Meeting was the ‘Application of nanostructures for preconcentration and determination of biological compounds and elimination of pollutants and drug delivery’. Nanostructure materials developed in various forms and sizes between nano and micro dimension. The unique physical, chemical and biological properties of these nanostructures tailored to achieve their desired applications for several biological compounds, activity against bacteria, adsorption of pollutants and for the delivery of drugs. The smaller surface area of nanoparticles increases its interactive, chemical activity and adsorption capability of heavy metals. Nanostructures developed sophistically to improve solubility and bioavailability for controlled drug release into the biological system. Nano materials such as activated carbon, grapheme, ferric oxide, magnesium oxide, manganese oxide, titanium oxide and zinc oxide used to develop sophisticated nanostructures for the removal of heavy metals. Organic and inorganic pollutants can be removed by nanostructures developed from the use of nano-catalysts e.g. Fenton based catalyst, photo catalyst and electro catalysts. Carbon nanotube membranes, hybrid nano-membranes and electrospun nanofibers used to remove dyes and heavy metals for their potential activity in removing pollutants and toxins. Nanostructures used for removal of heavy metals and various toxin developed in a way, that the final product is nontoxic to prevent any health hazards. Nanotechnology and nanoscience help developing variety of efficient, cost effective and eco-friendly nano-materials for variety of applications.

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    Role of toll-like receptors in IBD

    The topic of discussion on 18th June, 2018 at Journal Club Meeting was the ‘Role of toll-like receptors in IBD’. The TLRs is a class of transmembrane pattern recognition receptors that play key role in the induction of pro and anti-inflammatory genes and adaptive immunity. The TLRs recognize signals that can be of microbiota, viral, commensal, pathogen, or damage associated. Toll like receptor are the most important mediators for innate host defense of intestine involving in mucosal as well as commensal homeostasis. The TLR dysfunction is having mechanistic importance in IBD pathogenesis. The genetics, environment and immune system all in close interaction control the TLR function in the intestinal mucosa. Any imbalance within this multidimensional regulatory triad results in aberrant TLR signaling lead to acute and chronic inflammation in IBD. The TLRs expresses throughout the gastrointestinal tract and involve in specific expression at different anatomical sites. Perturbation between the gut flora and mucosal immunity causes gut inflammation in IBD in the genetically susceptible individuals. There are many TLRs agonist and antagonists under clinical trials for different diseases warranting investigation for IBD best treatment.

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    The emerging application of cold plasma in the healthcare industry

    The topic of discussion on 25th June 2018 at Journal Club Meeting was ‘The emerging application of cold plasma in the healthcare industry’. Plasma medicine is an emerging field that combines different fields such as life sciences, clinical medicine, and plasma physics. This field utilizes ionized gas that is the physical plasma for the medicinal and therapeutic purpose. Plasma is the fourth state of matter after solid, liquid, and gas. Source of plasma medicine is usually low-temperature plasma capable of generating ions or chemical reactive ions, atoms, molecules and ultraviolet photons. In this context, low temperature means room temperature or usually slightly above, to avoid skin burns that operates at atmospheric pressure. Plasma is partially ionized with < 1ppm of the gas being charged species and the remaining composes of neutral gas. Such plasma generated active and reactive species possess varied biomedical application, e.g. sterilization of surgical instruments and devices, modifying biomedical surface properties and cancer treatment. Most of the research performed until now is in vitro and in animal models.

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    The emerging application of cold plasma in healthcare industry

    Second session on ‘The emerging application of cold plasma in healthcare industry’ held on 02nd July 2018 at Journal Club Meeting. Biomedical plasma applications in dentistry include dental implant surface, enhancing of adhesive qualities and polymerization, surface coating and plasma cleaning. It is also used for microbicidal activities including decontamination, root canal disinfection and tooth bleaching. Various plasma devices developed for non-thermal atmospheric pressure plasma generation e.g. radio frequency plasma needles, direct current plasma brushes and plasma jets. Plasma oncology uses the cold atmospheric plasma (CAP) for tumor treatment. Several in vivo and in vitro studies presented CAP efficacy in reducing and halting tumor cell growth in low concentration. CAP is also capable of inducing cell death at higher concentration. CAP is found to be more effective than standard treatment against tumor. Dielectric barrier discharge and plasma jet showed significant anticancer capacity over several cell lines. Cold plasma offers chemical free and eco-friendly, non-thermal disinfection and surface modification technology. Plasma treated water is known as plasma activated water (PAW) creates an acidic environment by changing redox potential and conductivity, and generation of reactive oxygen and nitrogen species i.e. ROS and RNS. Comparatively to water, PAW has a different chemical composition and thus can serve as an alternative to microbial disinfection. Several studies have shown synergistic effect of PAW as disinfecting food, promoting seed germination, and plant growth. PAW present potential to increase crop yield especially in drought stress environment.