TIPS of the Tehran University of Medical Sciences

The Institute of Pharmaceutical Sciences (TIPS) is a new name for Pharmaceutical Sciences Research Center (PSRC) which was officially launched from February 2018. Drug Design and Development Research Center, and Pharmaceutics Quality Assurance Research Center are two joint centers of TIPS. TIPS tries to spread interest in research among students, to recruit and support researchers at all academic levels, to conduct both fundamental and applied ...

Read more »

Latest News   Archive

...

Meeting of Scientific Council in September 2018

TIPS scientific groups meeting was held by chairing of the TIPS head on 9th Sep. 2018. Important disscussions were made specially about the need to update sudies from the first step to the end. Also members were encouraged to develop the specialty groups of TIPS and promote industry-bases problem solvings. Head of TIPS encouraged all to adopt themselves with current fincial crisis and protect the projects as far as possible. Also head of TIPS emphasized that ethical rules must be taken into account in all studies.
...

پژوهشکده علوم دارویی کارگاه کمومتریکس برگزار می کند

برگزاری کارگاه "دوره آموزش مقدماتی کالیبراسیون تک متغیره" در پژوهشکده علوم دارویی
...

Ethics Workshop in TIPS

برگزاری کارگاه "ملاحظات اخلاقی در پژوهش های علوم دارویی" در پژوهشکده علوم دارویی
...

Scientific Council Meeting- October 2018

TIPS scientific groups meeting was held on 14 October 2018 and usual issues of TIPS were disscussed.

Journal Clubs

  • ...

    Reduction of marginal mass required for successful islet transplantation in a diabetic rat model using adipose tissue-derived mesenchymal stromal cells

    There are in vitro and in vivo studies reporting the regenerative role of Adipose tissue–derived mesenchymal stromal cells (AT-MSCs) possibly mediated by their protective effects on functional islet cells as well as their capacity to differentiate into insulin-producing cells (IPCs). In this study three different models including direct and indirect co-cultures and islet-derived conditioned medium (CM) to differentiate AT-MSCs into IPCs and to illuminate the molecular mechanisms of the beneficial impact of AT-MSCs on pancreatic islet functionality. Furthermore, combined in vitro co-culture of islets and AT-MSCs with in vivo assessment of islet graft function to assess whether co-transplantation of islets with AT-MSCs can reduce marginal mass required for successful islet transplantation and prolong graft function in a diabetic rat model. Our findings demonstrated that AT-MSCs are suitable for creating a microenvironment favorable for the repair and longevity of the pancreas β cells through the improvement of islet survival and maintenance of cell morphology and insulin secretion due to their potent properties in differentiation.

  • ...

    Artificial Enzymes

    At the journal club meeting Dr. Mehdi Mogharabi gave a presentation about artificial enzymes. A summary of his presentation can be seen in below: All living things in nature maintain their internal metabolic balances quite well when they are in healthy conditions. In other words, metabolic materials are in equilibria in each living creature primarily in a collaboration of biological catalyses by numerous enzymes. In consideration of such physicochemical roles of enzyme proteins, we are allowed to use man-made materials for construction of artificial enzymes that are capable of simulating catalytic functions demonstrated by enzyme proteins.

  • ...

    Weight-loss pills: Solution or illusin

    At the journal club on October 15, 2018, Fatima gave a talk about Weight-loss pills. She explained that obesity is a medical condition defined by excess body fat associated with negative health problems. It can be diagnosed using the body mass index (BMI). Obesity can be caused by excessive calorie intake, medical conditions such as Prader-Willi syndrome, polycystic ovary syndrome, osteoarthritis, and genetics. Obesity can be managed by lifestyle modification, weight loss pills, and surgery. Drugs such as Sibutramine, Orlistat, Liraglutide, are FDA approved though associated with severe side effects. At the end of her presentation she concluded that the use of pills may not be a solution since it is only effective over a long period of time. Healthy eating habit and increased physical activity remains the best option for management of obesity.

  • ...

    Destructive effect of non-enzymatic glycation on catalase and remediation via curcumin

    Non-enzymatic glycation of proteins is a post-translational modification produced by a covalent binding between one molecule of glucose and free Ɛ- amino group of amino acid specially lysine residue. The effect of pathological conditions, derived from hyperglycemia on catalase as an important antioxidant enzyme was considered by measuring enzyme activity, amount of reactive oxygen species (ROS) production, and changes in catalase conformational properties. It is observed that in the presence of glucose, the catalase activity gradually decreased with an increase in the ROS generation. Changes in the structure of the enzyme were also considered as another result of glycation. However, inhibitory effect of curcumin on structural changes and activity decrease of catalase were also investigated using experimental and computational methods. It was showed that interaction of catalase with curcumin resulted in changes in accessible surface area (ASA) and pKa as two effective parameters of glycation.