Developing new treatments for brain arteriovenous malformations: molecular responses to radiation in in vitro and in vivo models

  12/29/2020

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At TIPS journal club meeting held virtually on December 28, 2020, the topic of “Developing new treatments for brain arteriovenous malformations: molecular responses to radiation in in vitro and in vivo models” was presented by Dr. N. Raoufi-Rad, Australian School of Advanced Medicine, Macquarie University, Sydney, Australia. The intercellular adhesion molecule 1 and vascular cell adhesion molecule 1 are assumed to be potential candidates for vascular targeting of irradiated arteriovenous malformations as a leading cause of stroke in children and young adults. In this meeting the expression level of these molecules in cultured brain endothelial cells over a range of radiation doses was presented.